Always carry chambered, I'm of the belief that if you aren't comfortable carrying one chambered, you shouldn't carry at all. As long as you aren't taking your gun out and playing with it, why would it matter. Now personally I don't carry in the Appendix location as the OP was talking about, just because I can conceal a full sized 1911 or a Sig 226 well enough at 4:30 IWB, not to mention my 229 during the summer. Pretty good for someone with an athletic build. Carrying without one in the chamber add ones more step, one more thing that you need to train doing, and one more thing to go wrong. What if you are shot in one arm and can't chamber a round? Do you practice chambering a round one handed?